What is the catalog number for Recombinant Rat Interleukin 13 (rRtIL-13)?

The catalog number for Recombinant Rat Interleukin 13 (rRtIL-13) is orb1495001.

What sizes are available for Recombinant Rat Interleukin 13 (rRtIL-13)?

Recombinant Rat Interleukin 13 (rRtIL-13) is available in the following size(s): 1 mg, 2 µg, 10 µg.

How many pack sizes does Recombinant Rat Interleukin 13 (rRtIL-13) come in?

Recombinant Rat Interleukin 13 (rRtIL-13) is available in 3 different pack sizes.

Is Recombinant Rat Interleukin 13 (rRtIL-13) in stock?

Recombinant Rat Interleukin 13 (rRtIL-13) is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant Rat Interleukin 13 (rRtIL-13)

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma.

Product Specifications

Source

Escherichia coli.

Field of Research

Immunology & Inflammation

Endotoxin

Less than 1EU/μg of rRtIL-13 as determined by LAL method.

Purity

>95% by SDS-PAGE and HPLC analyses.

Bioactivity

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 1-4 ng/mL.

Form

Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.

Molecular Weight

Approximately 12.1 kDa, a single non-glycosylated polypeptide chain containing 110 amino acids.

Storage Conditions

This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

Notes

For research use only.

Applications Notes

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.