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YKL-06-061

YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively[1].

Product Specifications

CAS Number

2172617-15-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Salt-inducible Kinase (SIK)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ykl-06-061.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C1N(C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)C)=NC=C2CN1C5=C(C=CC=C5C)C)C6CCC6

Molecular Formula

C30H37N7O2

Molecular Weight

527.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19 (11) :2177-2184.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIK1

Available Sizes

Frequently Asked Questions

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