Naph-Se-TMZ

Naph-Se-TMZ is a PROTAC-like HDAC1 degrader. Naph-Se-TMZ can reduce the total HDAC activity in glioma cells and enhance the inhibitory effect of Temozolomide (HY-17364) . Naph-Se-TMZ consists of the target protein ligand (red part) Temozolomide (HY-17364), the DNA-targeting intercalator (blue part) Nitro-Naphthalimide-C2-acylamide (HY-169437) and the molecular linker (black part) . At the same time, the active control of the target protein ligand is: Temozolomide-amino hydrochloride (HY-169439), and the DNA targeting intercalator + linker is: NNISC-2 (HY-169438) [1].

Product Specifications

UNSPSC

12352005

Target

HDAC; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/naph-se-tmz.html

Smiles

[Se]=C(NNC(C1=C2N(C(N(C)N=N2)=O)C=N1)=O)NCCN(C(C3=C4C(C=C(C=C54)[N+]([O-])=O)=CC=C3)=O)C5=O

Molecular Formula

C21H16N10O6Se

Molecular Weight

583.38

References & Citations

[1]Sharma S, et al. Synthesis and characterization of a novel Naphthalimide-Selenium based Temozolomide drug conjugate in glioma cells. Bioorg Chem. 2024 Nov 26;154:107998.