ALK5-IN-34
ALK5-IN-34 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 can inhibit the activity of ALK5-IN-34 with an IC50 value of ≤10 nM. ALK5-IN-34 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer[1].
Product Specifications
CAS Number
[2785430-90-0]
UNSPSC
12352005
Target
TGF-beta/Smad; TGF-β Receptor
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-34.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=CC2=C(NC3=NC(NC4=CC=CC(N5CCOCC5)=C4)=NC=C3)C=NN=C12
Molecular Formula
C23H23N7O
Molecular Weight
413.48
References & Citations
[1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent. WO2022126133A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK5
Available Sizes
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