GSK1292263
GSK-1292263 is an orally available GPR119 agonist with pEC50s of 6.9 and 6.7 for human and rat GPR119, respectively. GSK-1292263 can be used for the research of type 2 diabetes mellitus (T2DM) [1].
Product Specifications
CAS Number
1032823-75-8
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
GPR119
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GSK1292263.html
Purity
99.71
Solubility
DMSO : ≥ 20 mg/mL
Smiles
CC(C1=NOC(N2CCC(CC2)COC3=CN=C(C=C3)C4=CC=C(C=C4)S(C)(=O)=O)=N1)C
Molecular Formula
C23H28N4O4S
Molecular Weight
456.56
Precautions
H302, H315, H320, H335
References & Citations
[1]X. Zhu, et al. GPR119 Agonists: A Novel Strategy for Type 2 Diabetes Treatment.|[2]Koji Matsumoto, et al. DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats. J Pharmacol Exp Ther. 2018 Dec;367 (3) :509-517.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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