Dolasetron
Dolasetron (MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
Product Specifications
CAS Number
115956-12-2
Product Name Alternative
MDL-73147
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dolasetron.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 300 mg/mL
Smiles
O=C(C1=CNC2=C1C=CC=C2)O[C@@H]3C[C@@](CC4C5)([H])[N@](CC4=O)[C@@]5([H])C3
Molecular Formula
C19H20N2O3
Molecular Weight
324.37
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7 (1) :50-8.|[2]Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) . Support Care Cancer. 2014 Feb;22 (2) :469-77.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Lactoferrin
Available Sizes
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