Dolasetron

Dolasetron (MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Product Specifications

CAS Number

[115956-12-2]

Product Name Alternative

MDL-73147

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dolasetron.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 300 mg/mL

Smiles

O=C(C1=CNC2=C1C=CC=C2)O[C@@H]3C[C@@](CC4C5)([H])[N@](CC4=O)[C@@]5([H])C3

Molecular Formula

C19H20N2O3

Molecular Weight

324.37

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7 (1) :50-8.|[2]Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) . Support Care Cancer. 2014 Feb;22 (2) :469-77.