Recombinant Human Stromal-Cell Derived Factor-1beta/CXCL12 (rHuSDF-1b/CXCL12)

Stromal-Cell Derived Factor-1 beta (SDF1β), also known as SCYB12, PBSF and CXCL12, is an 8.3 kDa, heparin-binding member of the CXC (or alpha) family of chemokines and signal through the CXCR4 receptor. SDF1α and β are reported to be monomers at neutral pH and physiologic ionic strength, On the cell surface, this may well facilitate SDF1 interaction with its two receptors, CXCR4 and syndecan4. Heparin sulfate is known to protect SDF1 from proteolysis, and CXCR4 exists constitutively as a dimer. Among its many functions, CXCL12 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis (12, 13) . It also enhances the survival of myeloid progenitor cells.