Recombinant Rat Granulocyte- Macrophage Colony Stimulating Factor (rrGM-CSF)
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity.
Product Specifications
Source
Escherichia coli.
Field of Research
Immunology & Inflammation
Endotoxin
Less than 1EU/mg of rr GM-CSF as determined by LAL method.
Purity
>98% by SDS-PAGE and HPLC analyses.
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of Murine FDC-P1 cells is 1.0 x 108 units/mg.
Form
Lyophilized from a 0.2mm filtered solution in PBS, pH 7.4.
Molecular Weight
Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.
Storage Conditions
Notes
For research use only.
Applications Notes
Preservative
Lyophilized from a 0.2mm filtered solution in PBS, pH 7.4.
AA Sequence
MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
