RecombinantIL-5, Rat
Interleukin-5 (IL-5), produced by mast cells, T cells and eosinophils, is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF) . It can increase production and mobilization of eosinophils and CD34+ progenitors from the bone marrow. IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release.Recombinant rat Interleukin-5 (rrIL-5) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 113 amino acids each. A fully biologically active molecule, rrIL-5 has a molecular mass of 26.0 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Specifications
Product Name Alternative
Interleukin-5, IL5
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE analysis.
Bioactivity
ED50 2.5x 10ˆ6 units/mg.
Form
Lyophilized after extensive dialysis against 20mM Tris, pH 8.5.
Molecular Weight
26.0 kDa, observed by non-reducing SDS-PAGE.
Storage Conditions
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/mL.
Preservative
Lyophilized after extensive dialysis against 20mM Tris, pH 8.5.
AA Sequence
MEIPMSTVV KETLIQLSTH RALLTSNETM RLPVPTHKNH QLCIGEIFQG LDILKNQTVR GGTVEILFQN LSLIKKYIDG QKEKCGEERR KTRHFLDYLQ EFLGVMSTEW AMEV
Available Sizes
Frequently Asked Questions
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