Cynomolgus IL-23 R Protein
Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Product Specifications
Product Name Alternative
IL-23 R, IL-23 Receptor
UniProt
G7NWY5
Expression Region
Gly 24 - Asp 353
Reactivity
Monkey
Conjugation
Unconjugated
Tag
C-Fc
Source
Cynomolgus IL-23 R, Fc Tag (orb1496206) is expressed from human 293 cells (HEK293) . It contains AA Gly 24 - Asp 353 (Accession # G7NWY5) .
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
95%
Form
Liquid
Molecular Weight
64.5 kDa
Storage Conditions
Notes
For research use only.
Applications Notes
NCBI Accession Number
G7NWY5
Preservative
PBS, pH7.4
Available Sizes
Frequently Asked Questions
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