Cynomolgus IL-23 R Protein
Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Product Specifications
Product Name Alternative
IL-23 R, IL-23 Receptor
UniProt
G7NWY5
Expression Region
Gly 24 - Asp 353
Reactivity
Monkey
Conjugation
Unconjugated
Tag
C-Fc
Source
Cynomolgus IL-23 R, Fc Tag (orb1496206) is expressed from human 293 cells (HEK293) . It contains AA Gly 24 - Asp 353 (Accession # G7NWY5) .
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
95%
Form
Liquid
Molecular Weight
64.5 kDa
Storage Conditions
Notes
For research use only.
Applications Notes
NCBI Accession Number
G7NWY5
Preservative
PBS, pH7.4
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
FVT1 (KDSR) (NM_002035) Human Over-expression Lysate
