RecombinantTPO, Mouse
Thrombopoietin (TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.
Product Specifications
Product Name Alternative
Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Source
CHO
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50 < 2 ng /ml, measured in a proliferation assay using MO7e cells.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
30-80 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml..
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
Available Sizes
Frequently Asked Questions
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