Levocetirizine (dihydrochloride)
Levocetirizine dihydrochloride ((R) -Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S) -Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].
Product Specifications
CAS Number
[130018-87-0]
Product Name Alternative
(R) -Cetirizine (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/levocetirizine-dihydrochloride.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.[H]Cl.[H]Cl
Molecular Formula
C21H27Cl3N2O3
Molecular Weight
461.81
Precautions
H302, H400
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Front Pharmacol. 2024 Aug 27:15:1413513.|Drug Metab Dispos. 2025 Mar;53 (3) :100046.
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