Orsellinic acid

Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea) . Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer) [1][2][3].

Product Specifications

CAS Number

[480-64-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Caspase; Drug Derivative; Fungal; PARP

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/orsellinic-acid.html

Purity

98.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C1=C(C=C(O)C=C1O)C)=O

Molecular Formula

C8H8O4

Molecular Weight

168.15

Precautions

H315, H319, H335

References & Citations

[1]Lopes TI, et al. Radical-scavenging activity of orsellinates. Chem Pharm Bull (Tokyo) . 2008;56 (11) :1551-1554.|[2]Bashyal BP, et al. Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum. J Nat Prod. 2005 May;68 (5) :724-8. |[3]Ryan SD, et al. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J Neurochem. 2007 Oct;103 (1) :88-97.