Largazole
Largazole ((+) -Largazole) is a potent and selective histone deacetylase (HDAC) inhibitor with antiproliferative activity. Largazole is able to modulate gene expression and affect cell growth and differentiation. Largazole has also shown potential application value in anti-tumor suppression[1].
Product Specifications
CAS Number
[1009815-87-5]
Product Name Alternative
(+) -Largazole
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/largazole.html
Smiles
CCCCCCCC(SCC/C=C/[C@H](CC(NC1)=O)OC([C@H](C(C)C)NC([C@]2(C)CSC(C3=CSC1=N3)=N2)=O)=O)=O
Molecular Formula
C29H42N4O5S3
Molecular Weight
622.86
References & Citations
[1]Synthesis and biological activity of largazole and derivatives
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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AP1S1, NT (AP1S1, AP19, CLAPS1, AP-1 complex subunit sigma-1A, Adapter-related protein complex 1 sigma-1A subunit, Adaptor protein complex AP-1 sigma-1A subunit, Clathrin assembly protein complex 1 sigma-1A small chain, Clathrin coat assembly protein AP19