Trifolirhizin

Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM[1]. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities[2].

Product Specifications

CAS Number

[6807-83-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TNF Receptor; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trifolirhizin.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC2=CC=C3C(OC[C@]4([H])[C@@]3([H])OC5=C4C=C(OCO6)C6=C5)=C2

Molecular Formula

C22H22O10

Molecular Weight

446.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Hyun SK, et al. Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis. Biol Pharm Bull. 2008 Jan;31 (1) :154-8.|[2]Zhou H, et al. Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots. J Agric Food Chem. 2009 Jun 10;57 (11) :4580-5.|[3]Hyun SK, et al. Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis. Biol Pharm Bull. 2008 Jan;31 (1) :154-8.