Limertinib (diTFA)
Limertinib (ASK120067) diTFA is a potent and orally active inhibitor of EGFRT790M (IC50: 0.3 nM) with selectivity over EGFRWT (IC50: 6.0 nM) . limertinib diTFA is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC) [1].
Product Specifications
Product Name Alternative
ASK120067 (diTFA)
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/limertinib-ditfa.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(NC2=NC=C(C(NC3=CC4=C(C=CC=C4)C=C3)=N2)Cl)=C(C=C1N(CCN(C)C)C)OC)C=C.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Molecular Formula
C33H34ClF6N7O6
Molecular Weight
774.11
References & Citations
[1]Tao Zhang, et al. Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance. Mol Cancer. 2020 May 13;19 (1) :90.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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