ACH-000143
Product Specifications
UNSPSC Description
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].
Target Antigen
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ach-000143.html
Smiles
CC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O
Molecular Weight
297.74
References & Citations
[1]Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138626/ACH-000143-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138626/ACH-000143-SDS-MedChemExpress.pdf
CAS Number
2225836-30-4
Available Sizes
Curated Selection
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