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ACH-000143

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].

Product Specifications

CAS Number

2225836-30-4

UNSPSC

12352005

Target

Melatonin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ach-000143.html

Concentration

10mM

Purity

98.58

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O

Molecular Formula

C13H16ClN3O3

Molecular Weight

297.74

References & Citations

[1]Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64 (4) :1904-1929.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MT1; MT2

Available Sizes

Frequently Asked Questions

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