UPF-523

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].

Product Specifications

CAS Number

[168560-79-0]

Product Name Alternative

AIDA

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/upf-523.html

Purity

99.89

Solubility

DMSO : 9.52 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic; adjust pH to 10 with NaOH)

Smiles

O=C(C1(N)CCC2=C1C=CC(C(O)=O)=C2)O

Molecular Formula

C11H11NO4

Molecular Weight

221.21

References & Citations

[1]Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326 (2-3) :105-108.|[2]Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1 (2) :151-161.