Totrombopag

Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology[1].

Product Specifications

CAS Number

[376592-42-6]

UNSPSC

12352005

Target

Thrombopoietin Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/totrombopag.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=NN5)=CC=C4)=CC=C3)C

Molecular Formula

C25H22N8O2

Molecular Weight

466.49

References & Citations

[1]Alper P B, et al. Discovery and biological evaluation of benzo [a] carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor[J]. Bioorganic & medicinal chemistry letters, 2008, 18 (19) : 5255-5258.