γ-Aminobutyric acid-4,4-d2

γ-Aminobutyric acid-4,4-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors) [2].

Product Specifications

CAS Number

[107022-06-0]

Product Name Alternative

4-Aminobutyric acid-4,4-d2

UNSPSC

12352211

Target

Endogenous Metabolite; GABA Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])(N)CCC(O)=O

Molecular Formula

C4H7D2NO2

Molecular Weight

105.13

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2.|[3]Okada R, et al. Gamma-aminobutyric acid (GABA) -mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514 (1) :74-91.|[4]Watanabe M, et al. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol. 2002;213:1-47.