(R) - (-) -Ibuprofen
(R) - (-) -Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R) - (-) -Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
Product Specifications
CAS Number
51146-57-7
Product Name Alternative
(R) -Ibuprofen
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-_-_-Ibuprofen.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](C1=CC=C(CC(C)C)C=C1)C(O)=O
Molecular Formula
C13H18O2
Molecular Weight
206.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NF-κB
Available Sizes
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