(R) - (-) -Ibuprofen

(R) - (-) -Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R) - (-) -Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

Product Specifications

CAS Number

[51146-57-7]

Product Name Alternative

(R) -Ibuprofen

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/_R_-_-_-Ibuprofen.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H](C1=CC=C(CC(C)C)C=C1)C(O)=O

Molecular Formula

C13H18O2

Molecular Weight

206.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.