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Met-RANTES (human)

Met-RANTES (human) is the antagonist for CCR1 and CCR5. Met-RANTES (human) inhibits chemokines human MIP-1α and MIP-1β with IC50 of 5 and 2 nM. Met-RANTES (human) reduces bone destruction and ameliorates rats adjuvant-induced arthritis (AIA) [1].

Product Specifications

CAS Number

1883816-50-9

UNSPSC

12352209

Target

CCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/met-rantes-human.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CCSC)N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]5CCCCN)=O)=O)CO)=O)[C@@H](C)O)=O)CC6=CC=C(O)C=C6)=O)CC7=CC=CC=C7)=O)CC8=CC=C(O)C=C8)=O)CCC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CC9=CNC=N9)=O)C)=O)CCCNC(N)=N)=O)CCC4)=O)CC(C)C)=O)CCC3)=O)CCCNC(N)=N)=O)C)=O)[C@H](CC)C)=O)CC%10=CC=C(O)C=C%10)=O)C)=O)CC%11=CC=CC=C%11)=O)CSSC[C@H](NC%12=O)C(N[C@H](C(N[C@H](C(N%13[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCSC)=O)CCC(O)=O)=O)CC(C)C)=O)CO)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC%14=CC=C(O)C=C%14)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC%15=CNC%16=CC=CC=C%15%16)=O)CCCCN)=O)CCCCN)=O)CCC(O)=O)=O)CCC%13)=O)CC(N)=O)=O)C)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N%17[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%12C(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)C(C)C)=O)CC%18=CC=CC=C%18)=O)C(C)C)=O)C(C)C)=O)C)=O)CCC%17)=O)CC(N)=O)=O)CO)=O)=O)CCC2)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O)CO)=O)CC%19=CC=C(O)C=C%19)=O)CCC1)=O)CO

Molecular Formula

C355H543N97O101S6

Molecular Weight

7978.07

References & Citations

[1]Shahrara S, et al., Amelioration of rat adjuvant-induced arthritis by Met-RANTES. Arthritis Rheum. 2005 Jun;52 (6) :1907-19.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

CCR1; CCR5

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