PROTAC FAK degrader 1
PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor. (Pink: Fak ligand (HY-44146) ; Black: Linker (HY-44141) ; Blue: VHL ligand 1 (HY-125845) ) [1].
Product Specifications
CAS Number
[2301916-69-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; FAK; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-fak-degrader-1.html
Purity
99.25
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
Molecular Formula
C47H56F3N9O8S2
Molecular Weight
996.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140 (49) :17019-17026.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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