Uracil

Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins[1][2][3][4][5].

Product Specifications

CAS Number

[66-22-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2,4_1H,3H_-Pyrimidinedione.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : ≥ 25 mg/mL

Smiles

O=C1NC(C=CN1)=O

Molecular Formula

C4H4N2O2

Molecular Weight

112.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.|[2]Viswanathan A, et al. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science. 1999 Apr 2;284 (5411) :159-62.|[3]Visnes T, et al. Uracil in DNA and its processing by different DNA glycosylases. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364 (1517) :563-8.|[4]Ikenaka K, et al. Effect of uracil on metabolism of 5-fluorouracil in vitro. Gan. 1979 Jun;70 (3) :353-9. |[5]de Koning HP, et al. A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport. Biochem Cell Biol. 1998;76 (5) :853-8.