Fiboflapon
Fiboflapon (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood[1].
Product Specifications
CAS Number
936350-00-4
Product Name Alternative
GSK2190915; AM-803
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FLAP; Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GSK2190915.html
Purity
99.50
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C(O)=O)(C)CC1=C(SC(C)(C)C)C2=CC(OCC3=CC=C(C)C=N3)=CC=C2N1CC4=CC=C(C5=CN=C(OCC)C=C5)C=C4
Molecular Formula
C38H43N3O4S
Molecular Weight
637.83
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
LTB4
Citation 01
Biochem Pharmacol. 2025 Oct 23:117451.|Universiteit Leiden. 2025.
Available Sizes
Frequently Asked Questions
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