UNC5293
Product Specifications
UNSPSC Description
UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research[1].
Target Antigen
Anaplastic lymphoma kinase (ALK); FLT3; TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc5293.html
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C)=NC(C)=C1)N2CCC(C3=CN([C@H]4CC[C@H](O)CC4)C5=NC(N[C@@H](C)CCC)=NC=C53)CC2
Molecular Weight
518.69
References & Citations
[1]Hongchao Zheng, et al. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 May 17;220:113534.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132200/UNC5293-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132200/UNC5293-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2226789-82-6
Available Sizes
Curated Selection
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