UNC5293
UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM) . UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research[1].
Product Specifications
CAS Number
[2226789-82-6]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; FLT3; TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc5293.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C)=NC(C)=C1)N2CCC(C3=CN([C@H]4CC[C@H](O)CC4)C5=NC(N[C@@H](C)CCC)=NC=C53)CC2
Molecular Formula
C30H42N6O2
Molecular Weight
518.69
References & Citations
[1]Hongchao Zheng, et al. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 May 17;220:113534.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Tyro3
Available Sizes
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TPX2 (P100, C20orf1, C20orf2, DIL2, HCA519, p100, Protein FLS353, Hepatocellular carcinoma-associated antigen 519, Targeting protein for Xklp2, Restricted expression proliferation associated protein 100, Differentially expressed in cancerous and noncancer
TPX2 (P100, C20orf1, C20orf2, DIL2, HCA519, p100, Protein FLS353, Hepatocellular carcinoma-associated antigen 519, Targeting protein for Xklp2, Restricted expression proliferation associated protein 100, Differentially expressed in cancerous and noncancer
