LY487379

LY487379 is a selective human mGluR2 positive allosteric modulator (PAM) . LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research[2].

Product Specifications

CAS Number

[353231-17-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly487379.html

Concentration

10mM

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(F)CS(=O)(N(C1=CC=C(OC2=CC=CC=C2OC)C=C1)CC3=CC=CN=C3)=O

Molecular Formula

C21H19F3N2O4S

Molecular Weight

452.45

Precautions

H302, H315, H319

References & Citations

[1]Nikiforuk A, et al. Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J Pharmacol Exp Ther. 2010;335 (3) :665-673.|[2]Schaffhauser H, et al. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol. 2003;64 (4) :798-810.