SIRT-IN-1
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 nM, respectively.
Product Specifications
CAS Number
[1431411-60-7]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SIRT-IN-1.html
Concentration
10mM
Purity
98.14
Solubility
DMSO : 19.23 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(C1=CC2=NC=NC(N3CCC(CCNC(C(C)(C)C)=O)CC3)=C2S1)=O
Molecular Formula
C19H27N5O2S
Molecular Weight
389.52
References & Citations
[1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56 (9) :3666-79.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3
Available Sizes
Curated Selection
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