HIV-1 TAT (48-60)

HIV-1 TAT (48-60) is a cell-penetrating peptide derived from the human immunodeficient virus (HIV) -1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way.

Product Specifications

CAS Number

[220408-24-2]

UNSPSC

12352209

Target

HIV

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/HIV-1_TAT_48-60.html

Purity

99.80

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N1[C@@H](CCC1)C(N[C@H](C(O)=O)CCC(N)=O)=O)[C@H]2N(CCC2)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC(CN)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C70H131N35O16

Molecular Weight

1719.01

References & Citations

[1]Vivès E, et al. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem. 1997 Jun 20;272 (25) :16010-7.|[2]Thorén PE, et al. Uptake of analogs of penetratin, Tat (48-60) and oligoarginine in live cells. Biochem Biophys Res Commun. 2003 Jul 18;307 (1) :100-7.|[3]Afonin S, et al. The cell-penetrating peptide TAT (48-60) induces a non-lamellar phase in DMPC membranes. Chemphyschem. 2006 Oct 13;7 (10) :2134-42.