Toltrazuril (sulfone)

Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry[1][2].

Product Specifications

CAS Number

[69004-04-2]

Product Name Alternative

Ponazuril

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Toltrazuril-sulfone.html

Purity

98.59

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(C=C1)OC2=C(C=C(C=C2)N3C(N(C(NC3=O)=O)C)=O)C)(C(F)(F)F)=O

Molecular Formula

C18H14F3N3O6S

Molecular Weight

457.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Sheila M Mitchell, et al. The effects of ponazuril on development of apicomplexans in vitro. J Eukaryot Microbiol. May-Jun 2005;52 (3) :231-5.|[2]Sheila M Mitchell, et al. Efficacy of ponazuril in vitro and in preventing and treating Toxoplasma gondii infections in mice. J Parasitol. 2004 Jun;90 (3) :639-42.