Terbinafine hydrochloride
Product Specifications
UNSPSC Description
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Antibiotic; Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/terbinafine-hydrochloride.html
Solubility
DMSO : 60 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CN(C/C([H])=C([H])/C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C21.[H]Cl
Molecular Weight
327.89
References & Citations
[1]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8.|[2]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-8.|[3]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82.Cancer Res. 2022 Sep 2;82(17):3032-3044.|Cell Death Dis. 2021 May 13;12(5):482.|Adv Healthc Mater. 2023 May 20;e2300018.|Adv Sci (Weinh). 2023 Sep;10(27):e2206878.|bioRxiv. 2024 May 14.|Cancer Commun (Lond). 2021 Jul 16.|Clin Transl Med. 2024 Feb;14(2):e1586.|Infect Drug Resist. 2022: 7459-7473.|Nat Microbiol. 2024 Feb;9(2):346-358.|Research Square Preprint. 2023 Sep 26.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17395/Terbinafine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17395/Terbinafine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
78628-80-5
Available Sizes
Curated Selection
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