Primaquine (diphosphate)

Primaquine diphosphate is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria[1].

Product Specifications

CAS Number

[63-45-6]

Product Name Alternative

Primaquine (phosphate) ; Primaquine (bisphosphate)

UNSPSC

12352005

Hazard Statement

H301, H341, H361

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Primaquine-Diphosphate.html

Purity

99.61

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(NC1=C2N=CC=CC2=CC(OC)=C1)CCCN.O=P(O)(O)O.O=P(O)(O)O

Molecular Formula

C15H27N3O9P2

Molecular Weight

455.34

Precautions

H301, H341, H361

References & Citations

[1]Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418.|[2]Qigui Li, et al. Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. Malar J. 2014 Apr 14:13:141. |[3]Ji-Hyang Kim, et al. Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation. Int J Mol Sci. 2021 Nov 30;22 (23) :12961.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Plasmodium

Citation 01

Adv Ther (Weinh) . 05 October 2021.|Ann Transl Med. 2021 Feb;9 (3) :194.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|ACS Omega. 2024 Feb 28;9 (10) :11870-11882.|Adv Sci (Weinh) . 2024 Nov 5:e2410285.