Seviteronel (R enantiomer)

Seviteronel R enantiomer (VT-464 R enantiomer) is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM) ; Seviteronel (VT-464) R enantiomer's activity is unknown.

Product Specifications

CAS Number

[1375603-38-5]

Product Name Alternative

VT-464 (R enantiomer)

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/VT-464-R-enantiomer.html

Purity

98.82

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC(F)OC1=C(OC(F)F)C=C(C=CC([C@@](C2=CNN=N2)(C(C)C)O)=C3)C3=C1

Molecular Formula

C18H17F4N3O3

Molecular Weight

399.34

References & Citations

[1]Rafferty SW, et al. Highly-selective 4- (1,2,3-triazole) -based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24 (11) :2444-7.|[2]Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models.  Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1