Purfalcamine
Product Specifications
Product Name Alternative
Y-39992
UNSPSC Description
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/purfalcamine.html
Purity
99.44
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(NC2=C3N=CN(C4=CC=CC(F)=C4)C3=NC(N[C@H]5CC[C@H](N)CC5)=N2)C=C1)N6CCCCC6
Molecular Weight
528.62
References & Citations
[1]Nobutaka Kato, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008 Jun;4(6):347-56.|[2]Rajshekhar Y Gaji, et al. Expression of the essential Kinase PfCDPK1 from <i>Plasmodium falciparum</i> in <i>Toxoplasma gondii</i> facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother. 2014 May;58(5):2598-607.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117015/Purfalcamine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117015/Purfalcamine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1038620-68-6
Available Sizes
Curated Selection
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