Friedelin (Standard)
Friedelin (Standard) is the analytical standard of Friedelin. This product is intended for research and analytical applications. Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia (Mart) . Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79 ?μM and 6.16? μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54? μM and 18.02 μM, respectively[1].
Product Specifications
CAS Number
559-74-0
UNSPSC
12352211
Target
Cytochrome P450; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/friedelin-standard.html
Smiles
C[C@@]12[C@]([C@@]3([H])[C@](C)(CCC(C)(C)C3)CC1)(CC[C@]4(C)[C@]2([H])CC[C@@]([C@H]5C)(C)[C@@]4([H])CCC5=O)C
Molecular Formula
C30H50O
Molecular Weight
426.72
References & Citations
[1]Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56 (1) :363-367.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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