CR 665
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].
Product Specifications
CAS Number
228546-92-7
Product Name Alternative
JNJ 38488502; FE 200665
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cr-665.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=NC=C1)[C@@H](CCCNC(N)=N)NC([C@@H](CCCC)NC([C@H](NC([C@H](N)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O
Molecular Formula
C36H49N9O4
Molecular Weight
671.83
References & Citations
[1]Anne E Olesen, et al. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet|[2]Francis M Hughes Jr, et al. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 2
Available Sizes
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