CR 665

CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].

Product Specifications

CAS Number

[228546-92-7]

Product Name Alternative

JNJ 38488502; FE 200665

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cr-665.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=NC=C1)[C@@H](CCCNC(N)=N)NC([C@@H](CCCC)NC([C@H](NC([C@H](N)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O

Molecular Formula

C36H49N9O4

Molecular Weight

671.83

References & Citations

[1]Anne E Olesen, et al. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet|[2]Francis M Hughes Jr, et al. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22.