Tiplaxtinin
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM[1].
Product Specifications
CAS Number
393105-53-8
Product Name Alternative
PAI-039; Tiplasinin
UNSPSC
12352005
Hazard Statement
H302+H312, H315, H318, H411
Target
Apoptosis; PAI-1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Tiplaxtinin.html
Concentration
10mM
Purity
99.03
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(C(O)=O)C1=CN(CC2=CC=CC=C2)C(C1=C3)=CC=C3C4=CC=C(OC(F)(F)F)C=C4
Molecular Formula
C24H16F3NO4
Molecular Weight
439.38
Precautions
H302+H312, H315, H318, H411
References & Citations
[1]Hennan JK, et al. Effect of Tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis. J Thromb Haemost. 2008 Sep;6 (9) :1558-64.|[2]Gomes-Giacoia E, et al. Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model. Mol Cancer Ther. 2013 Dec;12 (12) :2697-708.|[3]Hennan JK, et al. Evaluation of PAI-039 [{1-benzyl-5-[4- (trifluoromethoxy) phenyl]-1H-indol-3-yl} (oxo) acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis. J Pharmacol Exp Ther. 2005 Aug;314 (2) :
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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