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SHR-1701

SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

Product Specifications

CAS Number

2891860-17-4

Product Name Alternative

Retlirafusp alfa

UNSPSC

12352203

Target

PD-1/PD-L1; TGF-β Receptor

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shr-1701.html

Purity

99.77

Solubility

10 mM in DMSO

Smiles

S[R1701]

Molecular Formula

HS

Molecular Weight

(174.61 kDa)

References & Citations

[1]Bo Cheng, et al. Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer. Cancer Commun (Lond) . 2022 Jan;42 (1) :17-36.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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