MeBIO
MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively[1].
Product Specifications
CAS Number
667463-95-8
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
Aryl Hydrocarbon Receptor; CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mebio.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 14.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C)C2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\O
Molecular Formula
C17H12BrN3O2
Molecular Weight
370.20
Precautions
H228, H315, H319
References & Citations
[1]Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66. |[2]Knockaert, et al. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23.25 (2004) : 4400-4412.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK5; GSK-3
Available Sizes
Frequently Asked Questions
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