Telotristat

Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM.

Product Specifications

CAS Number

[1033805-28-5]

Product Name Alternative

LP-778902

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/telotristat.html

Purity

99.42

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

N[C@@H](CC1=CC=C(C2=NC(N)=NC(O[C@H](C3=CC=C(Cl)C=C3N4N=C(C)C=C4)C(F)(F)F)=C2)C=C1)C(O)=O

Molecular Formula

C25H22ClF3N6O3

Molecular Weight

546.93

Precautions

H315, H319, H335

References & Citations

[1]Lapuerta P, et al. Telotristat etiprate, a novel inhibitor of serotonin synthesis for the treatment of carcinoid syndrome. Clin. Invest. (Lond.) (2015) 5 (5), 447–456|[2]US20080153852

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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