Sox2 (phospho-Ser250/Ser251) rabbit pAb

SRY-box 2 (SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],

Product Specifications

Background

Product Name Alternative

Transcription factor SOX-2

UniProt

P48431

Swiss Prot

P48431

Reactivity

Human; Mouse

Immunogen

Synthesized phosho peptide around human Sox2 (Ser250 and Ser251)

Target

SOX-2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Buffer

-20°C/1 year

Molecular Weight

35kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

35kD

Fragment

IgG

Subcellular Location

Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity) . Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) . Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity) . Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity) . .