DTAG-47

DTAG-47 is a FKBP12F36V PROTAC degrader. dTAG-47 efficiently degrades FKBP12F36V-MELK (sg3R) in MELK⁻/⁻ MDA-MB-468-FKBP12F36V-MELK (sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC) . (Pink: FKBP12F36V ligand (HY-114420), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-42773), E3 ligase ligand-linker conjugate (HY-175952) ) [1][2].

Product Specifications

CAS Number

[2265886-81-3]

UNSPSC

12352005

Target

FKBP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dtag-47.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O

Molecular Formula

C59H73N5O14

Molecular Weight

1076.24

References & Citations

[1]Hai-Tsang Huang, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693.|[2]Sreekanth V, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS Cent Sci. 2020 Dec 23;6 (12) :2228-2237.