Sulfasalazine

Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

Product Specifications

CAS Number

[599-79-1]

Product Name Alternative

NSC 667219

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335, H350, H360

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; Ferroptosis; NF-κB

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Sulfasalazine.html

Concentration

10mM

Purity

99.32

Solubility

1 M NaOH : ≥ 100 mg/mL|DMSO : 80 mg/mL (ultrasonic; warming) |NH4OH : 150 mg/mL (ultrasonic; adjust pH to 9 with NH4OH)

Smiles

OC(C1=C(O)C=CC(/N=N/C2=CC=C(S(=O)(NC3=NC=CC=C3)=O)C=C2)=C1)=O

Molecular Formula

C18H14N4O5S

Molecular Weight

398.39

Precautions

H302, H315, H319, H332, H335, H350, H360

References & Citations

[1]Wahl C, et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998 Mar 1;101 (5) :1163-74.|[2]Sykes L, et al. Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes. Immunology. 2015 Dec;146 (4) :630-44.|[3]Chung WJ, et al. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. J Neurochem. 2009 Jul;110 (1) :182-93.|[4]Mao C, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593 (7860) :586-590.