Omadacycline (hydrochloride)
Product Specifications
UNSPSC Description
Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].
Target Antigen
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Omadacycline__hydrochloride_.html
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)[C@@H](N(C)C)[C@@](C[C@@]2([H])C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C2)=O)=C4O)([H])[C@@]4(O)C1=O)N.Cl
Molecular Weight
593.11
References & Citations
[1]Macone AB, et, al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014;58(2):1127-35.|[2]Durães F, et, al. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines. Pharmaceuticals (Basel). 2019 Apr 21;12(2):63.|[3]Zhanel GG, et, al. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb;80(3):285-313.|[4]Markham A, et, al. Omadacycline: First Global Approval. Drugs. 2018 Dec;78(18):1931-1937.J Antimicrob Chemother. 2021 Feb 11;76(3):653-658.|J Antimicrob Chemother. 2021 May 6;dkab141.|Virulence. 2022 Dec;13(1):77-88.|Animal Feed Science and Technology. 2014 Dec;198:323-332.|Ann Lab Med. 2021 May 1;41(3):293-301.|Antibiotics (Basel). 2022, 11(10), 1298.|Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19.|Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02097-19.|Antimicrob Agents Chemother. 2023 Jan 23;e0145922.|Clin Exp Pharmacol Physiol. 2023 Apr 22.|Comput Intell Neurosci. 2022 Apr 25;2022:7636983.|Diagn Micr Infec Dis. 2020 Nov;98(3):115129.|J Antibiot (Tokyo). 2022 Jun 27.|J Clin Microbiol. 2020 Jan 28;58(2):e01603-19.|Microbiol Spectr. 2022 Dec 8;e0323822.|Microbiol Spectr. 2023 May 4;e0071823.|Nat Microbiol. 2023 Mar;8(3):410-423.|Nat Struct Mol Biol. 2023 Aug 7.|Open Forum Infect Dis. 2024 Oct 11;11(11):ofae611.|PLoS Biol. 2022 Sep 28;20(9):e3001808.|Research Square Preprint. 2020 Jun.|Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0063824.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14865C/Omadacycline-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14865C/Omadacycline-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1196800-39-1
Available Sizes
Curated Selection
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