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CDK8-IN-1

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

Product Specifications

CAS Number

1629633-48-2

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CDK8-IN-1.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O

Molecular Formula

C11H8F3N3O

Molecular Weight

255.20

References & Citations

[1]Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27 (18) :4488-4492.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK8

Available Sizes

Frequently Asked Questions

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