What is the catalog number for CGAMP?

The catalog number for CGAMP is HY-12512.

What sizes are available for CGAMP?

CGAMP is available in the following size(s): 1 mg, 5 mg, 10 mg, 25 mg.

How many pack sizes does CGAMP come in?

CGAMP is available in 4 different pack sizes.

CGAMP is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CGAMP?

CGAMP is manufactured by QuantiMol.

What is the estimated delivery time for CGAMP?

Estimated delivery time for CGAMP is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CGAMP?

The safety data sheet for CGAMP is available here: http://file.medchemexpress.com/batch_PDF/HY-12512/cGAMP-SDS-MedChemExpress.pdf.

CGAMP

CGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

Product Specifications

CAS Number

849214-04-6

Product Name Alternative

Cyclic GMP-AMP; 3',3'-cGAMP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cGAMP.html

Purity

99.22

Solubility

H2O : 180 mg/mL (ultrasonic)

Smiles

O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5

Molecular Formula

C20H24N10O13P2

Molecular Weight

674.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339 (6121) :826-30.|[2]Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9 (10) :e110150.|[3]Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371 (6) :507-18.|[4]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503 (7477) :530-4.